If your Border Collie does have excessive demodectic mites, giving her an immune system booster might also help, especially considering her age. Thank you. (Most vets are going to recommend to you the products they carry in stock, but you can order online from Chewy or pet pharmacies.) Before I got them home, they went into comas. Basically, while the FDA has not pulled these drugs from the market, it has asked the product manufacturers to add precautions to their labels while it continues to monitor information submitted by veterinarians, the companies themselves, and individual product users. Hi, Thank you for this helpful article. Giardia can be passed to and cause diarrhea in humans. Material name: Simparica Trio Version #: 01 Issue date: 07-01-2019 SDS US. Our cat does not socialize with the Collies. . Product Description. After doing further research I am very reluctant to give her any of these medications, however, I wasnt finding clear answers on what a safe alternative was until I found your article. I went through Paw Print Genetics to save money. Thanks. Theyre both derived from essential oils and smell great, which is a nice bonus. We had a wonderful smooth girl for years and while many of the medication names here sound familiar, I cant remember what we gave her. Our vet recommended Bravecto because he said it had been specifically tested on dogs with the MDR1 gene. I am going to try WonderCide as recommended by my Vet for fleas. Good luck with the puppies, and I hope they get healthy soon. To make dosing easy, it's available for dogs in six sizes based on body weight range: Gold: 2.8-5.5 pounds. According to Dr. Jean Dodds of Hemopet, researchers and veterinarians thus far cannot point to breed characteristics, age group, drug interactions or genetic mutations as contributing factors to the latest findings that prompted the FDA warning. In other words, the reported adverse reactions to Bravecto had nothing to do with whether or not a dog had MDR1. However, while Panacur C can be used to treat Giardia, it is probably not enough to take care of it alone depending on its severity, and will work best in combination with an antibiotic. But Ive given it a caution designation as it should not be given in combination with heartworm meds and is not safe for dogs who are at risk for seizures. 1 x 5mg tablet for 2.8 to 5.5 pounds. My personal quest to find the safest parasite protection for dogs known to carry the MDR1 (Multi Drug Resistance) gene led me on a merry chase. A negative heartworm test is crucial prior to beginning administration of diethylcarbamazine. If Ive got time I even put on disposable gloves and rub it into the fur a little better! The login page will open in a new tab. Waxman and Brooks both recommend it. THREE OF THE 8 FEMALES WENT INTO ESTRUS. Your article was appreciated and helpful! We do, however, have lots of deer ticks (also known as black legged ticks). Hi! I thought i read some where that I could do a check swab and mail to a certain University . Maybe regular Interceptor would be fine since it doesnt contain Praziquantel, but its difficult to say exactly what your dog is reacting to. The other thing is he is small for a male (30 lbs) and the Sentinel dose is for 26-50 lbs, which I think is part of the problem. Still, if you live in the city and dont walk your dogs through long grass or woodsy areas, this could be a great choice for you. Simparica Trio is the first and only product that combines sarolaner, moxidectin, and pyrantel in one simple-to-give chewable-for protection against heartworm disease, ticks & fleas, roundworms & hookworms.. One chewable tablet provides month-long protection for all dogs over 8 weeks old and weighing 2.8 pounds or more. Simparica Trio Chewable Tablets for Dogs. SIMPARICA TRIO tested positive for heartworm disease. My pleasure! This is a new extensively tested product now available in Australia that provides optimal protection for your dog. Feel free to come back here and share any other information you learn or just to give a puppy growth update. Select in Checkout From an MDR1 standpoint, Simparica is *technically* safe; but I am leery of it considering the FDA warning about isoxazolines ("-laner" medications) I discussed in the article. I like to sprinkle some around the perimeter of my yard and lay an inner circle around the edges of my house which probably looks like Im trying to keep out evil fairies and other fantasy creatures. (I didnt find the information about the 6 reported seizures until after I had already given it to my dogs and seen no ill effects from it.) We can eat it. Be prepared to answer questions about whether your dog had a previous history with seizures, has any drug sensitivities, if anything else could possibly have triggered a seizure, and if she has had any seizures since the collar was removed. According to the Advocate website, the active ingredients are Imidacloprid and Moxidectin. Simparica. Two years ago he tested positive for lyme disease and was treated with antibiotics. You might want to look at the information on Nexgard. Another safe heartworm medication is the daily dimmitrol. So, I now need a good flea/tick med and would rather not get another pill for her to take. Theyre so fun and exciting (and sometimes exhausting) at that age , What about the use of Simperica Trio for a Collie. We gave her the first dose in late February and there were no adverse side effects for Sugar. Turns out it is also used for the treatment and prevention of roundworms and lungworm nemotodes in dogs, according to Vet Shop Max. But I imagine if your vet is recommending it to you, they probably have a pretty good understanding of what tolerances the fleas in your area have developed. We are waiting for the results from her test for the MDR1 gene. . She has always had a sensitive stomach, but as she gets older, it gets worse. However, it did make my Collies too itchy. If you think about it, come back here and let me and other readers know what worked best for you! . Since I live in Florida, Revolution is not the best choice for me as it only targets the dog tick. The Wondercide website says, We recommend testing any new product you introduce to your pet or environment eight hours prior to a full application to ensure there are no sensitivities. With cedar oil being the main ingredient, it should be relatively safe; but its best to be cautious, especially as your girl has proven to be so sensitive. Just want to do what is best for them? Your thoughts? Im just looking for advice as to tick prevention medication. Personally, my Roughs have sensitive skin plus I have a household cat, so Id try Frontline Gold first. Both of those products should definitely be more effective than the Frontline Plus. . Thank you very much! And thank you for saying so. Dogs with normal MDR1 genes can usually tolerate oral dosages as high as 2,500 mcg/kg of body weight before signs of toxicity are seen, while dogs with two copies of the defective MDR1 gene can tolerate only up to 100 mcg/kg of oral ivermectin. From what youve told me, that does sound highly suspect. enough to have 4 dogs like I do! Do you know what the ingredients are in the medicated shampoo? Ive been accused of being overly cautious when it comes to my dogs, but I admit to being a better safe than sorry kind of person! Thank you so much for writing this article!!! (Your vet or a pet store associate may recommend otherwise, but bear in mind that they also want to make money.). Roxie has never been tested, but she is Dashs niece so probably also mutant/normal if I were to guess. Freckles my Aussie/Pyr is such a great dog. Would this be your recommendation? The vet thought he would be nice and put Advantage Multi on our cats. Unlike many other external parasite treatments that only kill little bloodsuckers after theyve bitten the dog, K9 Advantix claims to kill them on contact. The article mentioned Seresto covered 4 kinds of ticks, so Im glad you clarified your selection for me. Since Collies and cats go together so well, I have to include this caution for cats: Some ingredients used to kill ticks, such as permethrin (used in K9 Advantix and other products) and amitraz (used in Certifect and the Preventic collar), are toxic to cats, which can be a problem in a household that includes both, especially if they are friendly with each other. If you have cats that share sleeping space with and/or like to groom your dogs, Advantix is probably not the best product for you. 5 A dog's reaction to flea bites may vary from sores and inflammation to hair loss. Although it would be very hard to determine exactly which component of a combination medication your Collie is reacting to, your girl might be less likely to have a reaction to Interceptor (regular, not Plus), as it only has one active ingredient as opposed to the two active ingredients in Sentinel. One thing about Credelio is that it only breaks the flea life cycle at one point (kills adult fleas only after they bite the dog), so you may want to use a natural flea & tick repellent spray to increase its effectiveness. Thank you! Components Species Test Results Silica colloidal, Ph. Dogs with the MDR1 genetic mutation can become very ill or die if given certain medications. Your such a good writer,thank you so much for posting this very informative article.In this way it will greatly help keep our pets safe. We use interceptor for heartworms and was using frontline until she recently started having negative reactions to it. We have an 11 year old tricolor rough coat collie. Rich Soil gives this excellent explanation of what DE is and how it works: the fossilized remains of marine phytoplankton. The product was well tolerated in dogs with a deficient multidrug-resistance-protein 1 (MDR1 -/-). If the veterinary staff cant see they are prescribing the wrong combination of medications, maybe you can point it out to them.. In a laboratory study, the product was . Regardless of the heartworm product you choose, as the Institute of Pharmacology and Toxicology says, treatment of MDR1 mutant dogs with macrocyclic lactones in general requires particular caution. It really boils down to weighing the benefits of medications against the risks from internal parasites. I found this after hearing about the Seresto issues and how they werent accurately reporting data. The product insert states Do not use this product on debilitated, aged, medicated, pregnant or nursing dogs, or dogs known to be sensitive to pesticide products., If you live in a seasonal region where you actually experience winter complete with freezing temperatures and snow, and your pets have been on regular pest preventive products, you can give them a break from chemicals for a few months while the insects are dormant. On the second dose she went into an extreme false heat. This was shown by panting , pacing, and curling her tail to show being receptive for breeding. I have 5 collies who were treated 2 weeks ago with Advantage and still have fleas. I have a 3 year old and an 11 week old Australian Shepherd. He loves the taste of Simparica Trio and it's like a treat . I have two Rough Collies who are MDR1 carriers and an Aussie mix, so I have a vested interest in everything Ive researched. With seizures it's tough to pinpoint the cause (without extensive testing), so vet recommended . Ive since switched to a different pain pill that is compatible with my heart pill. If you are able to keep your dogs separated from your cats for 24hrs, the added protection against mosquitoes that K9 Advantix II provides from the possible diseases they carry seems like a greater pro to con ratio. -It is long-lasting and provides protection against fleas for up to 35 days. Theyre so fun and crazy at that age. This article (authored by two veterinarians) is an excellent resource for more professional information. Any dog can have a sensitivity to a certain substance and should always be monitored for reactions after a new product has been administered. Oh no! I do remember her cowering and rubbing her back against her crate after we administered anything topical! After her first heat she went into a false pregnancy. The tail curling and pacing lasted over a week. I have never even heard of the latter and do not believe they exist in Canada. Happy to help! Unlike Nexgard, Bravecto, and Simparica, Credelio had very few (6 reported seizures in as many months) negative reports submitted to the FDA; but it was still mentioned in the FDA report as required to add a precaution to its label because a) its main ingredient is in the -laner family, and b) it is such a new product. These four ML compounds (ivermectin, moxidectin, selamectin, and milbemycin oxide) have been officially approved by the FDA (Federal Drug Administration) and tested safe for MDR1 dogs when administered at the recommended preventative dosage. new post updates in monthly email newsletters. I just picked out a beautiful tri color rough collie this morning! If you live in an area where the fleas just refuse to die, you may want to consider an alternative, stronger product. I thought I initially replied to your comment back in December, but I was just reviewing the comments section and it looks like my reply never posted! Is hartz ultraguard ear mite treatment for dogs safe? You should still keep an eye on your pet when introducing new organic products. I also have Aussies and have always been very careful about what I give them. As an aussie, I like to assume he's an MDR1 carrier therefore can be reactive to certain meds. I got an email from the rescue agency that fussed that I hadnt given them their heartgard for this month. Besides safety, Revolution is an attractive option because of its ease of application (topical squeeze-on tube) and versatility in treating heartworm, fleas, dog ticks, sarcoptic mange, and even ear mites. Katie P. 11 days ago. Im trying to find out if this is safe for her. Any thoughts? Simparica Trio Chewable Tablets for Dogs works to prevent heartworms as well as treat lone star ticks, black-legged ticks, Gulf Coast ticks, American dog ticks, brown dog ticks, fleas, roundworms, and adult hookworms. (I googled veterinary pharmacists near me and found one locally, but Jacksonville is a huge city.) My vet wants to give him a vaccine (?) I looked up potential side effects for the new pill, and sure enough, the product info for the pain medication specifically advised that it should not be taken with blood pressure medication. It is supposed to repel mosquitoes as well but I am very nervous about not using a heart worm preventative. We have an MDR1 heterozygous Aussie and this was the best breakdown of the meds we found. If you choose to use Advantage Multi, great care should be taken to only apply the liquid between your dogs neck and shoulder blades, where it cannot be reached by licking. Dogs, 6 Month Supply removed from the wishlist. Bottom line is that Simparica will probably be fine for your dog, but there is a slight risk that it wont. If you havent yet tried Interceptor for heartworm prevention, I would suggest that for you. In a wellcontrolled 60day US field study conducted in dogs with existing flea infestations of varying severity, the effectiveness of SIMPARICA TRIO against fleas on Day 30 and 60 visits was 99.0% and 99.7%, respectively, After talking to a variety of Collie people, Frontline seems to be the most trusted of the topical flea/tick products available. Thank you for writing this article. Some swear by food grade DE (diatomaceous earth) as a natural dewormer of roundworms, hookworms, whipworms, and even tapeworms. Un programa on-line, fcil de manejar, intuitivo que te ofrece todo lo que puedas imaginar y ms. Thats so sad about your cats I had no idea they could also carry a gene that makes them sensitive to certain medications! They both have tolerated Bravecto very well.no noticeable side effects. He said Elanco is very conscientious about safety (particularly since Interceptor is used by so many people who have MDR1-prone dogs), and even with his advice I still stood there reading the label and agonizing over my decision before I decided to give it a try! Thank you, and hello to Nola and Otis! (My dogs dont groom each other or really play that way now that theyre older and settled, so I feel comfortable using topicals now.) Frontline Shield has Permethrin and Pyriproxifen, so my concern would be that those 2 ingredients together would be stronger and potentially cause skin irritation. Capstar specifically targets adult fleas, so it is best paired with a product like Sentinel. I did write this article a couple of years ago; but I have updated it several times since most recently after information came out about some fatal reactions to Seresto collars. ), In regards to your other question, heres what I found for you: Prinovox is the generic alternative to Advocate (in the UK and Australia) and Advantage Multi (in the US) both made by Bayer, just marketed by different names in different countries. Another danger often lies in a treated dog being exposed to additional environmental pesticides, which can lead to an accidental overdose. I follow this advice, since Im a safe-is-better-than-sorry person. Advantage Multi can be a great product when used with care, and I would expect the same to be true for Advocate. We need more people like you. (I did try to use it to deworm my cat without great success, but that could just be because I couldnt get him to ingest a complete dose at once.) Thank you for the positive feedback. I personally prefer something gentler as many Collies can have sensitive skin, but it really depends on the dog. Much appreciated! If youre hoping for a quick, easy skim and just want to know which pest protections are considered safe, Ill list those first under each heading, followed by the use with caution category, and finally the not safe options. Your article has been very helpful in my quest to help my forest loving dog stay safe from tics. Its simpler to identify medicines by their components, since many of them are essentially the same thing marketed under different brand names. Is Simparica safe for MDR1 dogs? Simparica Trio is the first and only product that combines sarolaner, moxidectin and pyrantel in each treatment to help prevent heartworm disease, kill fleas before they can lay eggs, kill 5 types of ticks, treat and prevent flea infestations and treat and control roundworms and hookworms. Im not a veterinarian and would of course recommend that you consult with yours, but I do think that dogs vary individually (just like people) and can react differently to certain medications. Simparica TRIOse administra va oral una vez al mes, a una dosis de 1.2 mg de sarolaner/kg de peso corporal; . Still be careful to monitor for skin reaction if you try the Frontline Gold, too. She is just 1 year old. Simparica Trio chewable tablets for dogs 1.25-2.5 kg Simparica Trio chewable tablets for dogs >2.5-5 kg . I had success giving Credelio (active ingredient lotilaner instead of Simparicas sarolaner), but in all honesty I administered that based on my vets recommendation BEFORE I realized the FDA warning also applied to Credelio. Thanks! Shes been a red hot mess and Im not convinced Simparica isnt the cause(stomach issues, hyper activity(I raised a border so ready for energy but this is frenetic) and not sleeping more then 30- 40 minutes at a time. This is typically due to a specific genetic mutation (MDR1) that makes them less able to tolerate high doses of ivermectin. The topical medicines seem to work best with her, but dont do much to keep the tics at bay. After 24 hours, it is considered waterproof and a bath, while alleviating some effects, will not offer as much relief. This is so thorough and helpful! I interviewed a few people (rescue workers, owners, and breeders) from that group for this article I wrote about Border Collies. Hi Emily, do you know if panacure is a safe wormer? Hi, I was just wondering if you still use credelio for flea prevention? So far, noone has the answer to this seemingly-simple question as to what ticks their product actually acts against. Background: The efficacy and safety of a novel isoxazoline compound, sarolaner (Simparica , Zoetis) and spinosad (Comfortis , Elanco) as a positive control were evaluated for the treatment and control of natural flea infestations on dogs in two randomised, blinded, multi-centric clinical trials conducted in 11 veterinary clinics in northeastern and southeastern states of Australia. Simparica TRIO is a monthly chew with triple protection against the three biggest threats facing our dogs today - fleas and ticks, intestinal worms and deadl. is it safe or not to use it? I just dont know what to do about heartworm treatment and wonder if Interceptor instead of Interceptor Plus would be a better option or more of the same. Simparica Trio (sarolaner, moxidectin and pyrantel) tablets for dogs; . Dr. Morgan concluded her story with: Be your pets advocate. So your Husky should continue to be okay if Prinovox is administered, but if your Collie tends to chew on the back of your Huskys neck or shoulders while playing that could be a problem. (Bacon) 3.8 (6,612) $2691 ($0.19/Count) $24.22 with Subscribe & Save discount. Because of their similarity to Heartgard, Ive placed them in the same caution category. My Aussie/Pyrenees mix has had no issues with it, for instance. Any suggestions? Thank you!! Astfel, produsul Simparica Trio Caini (40.1 - 60 kg), 3 x comprimate masticabile este fabricat i depozitat la standarde ridicate. Based on my findings, Im not convinced of its superior safety. So called vet and they said topically we should try Parastar Plus. However, the medicine can be passed through a mothers milk: so it is not recommended for pregnant or nursing female dogs, though it is safe for puppies 8 weeks of age and older. My dogs are on Sentinel right now and Frontline Gold. I have an 8 year old BC and a 12 week old English Shepherd/Rough Collie mix. Thank you! On the down side, it does not cover any ticks. Last year I used Frontline Plus with no issues. Australian Shepherds have a slightly lower incidence, with 50% being affected . I know youre very particular about the genetic health of your Collies, and I admire your breeding program. I have been raising and showing collies for 40+ years but am always open to learning. This gave me a great start for research. Thank you for such a great article! Is Frontline Plus still safe? I have a unique situation. These generics include Tri-Heart Plus, Iverhart Plus, and Nuheart. It is safe for use with anthelmintics like heartworm meds and has no known negative drug-drug interactions. No one knows yet why some dogs react to isoxazolines like Simparica and others dont, and theres no way to know until its tested on an animal. Class A DO NOT use these drugs in dogs with the MDR1 Gene Defect Ivermectine substances "Anti parasites": (Diapec, Ecomectin, Equimax, Eqvalan, Ivomec, Noromectin, Paramectin, Qualimec, Sumex, Virbamec) Doramectine substances "Anti parasites": (Dectomax ) Simparica TRIO contains three active pharmaceutical ingredients, sarolaner, moxidectin, and pyrantel pamoate. This monthly chewable is recommended for 8 weeks and older dogs, weighing 2.8 lbs or more. The active ingredients in Hartz look pretty harsh, so Id be concerned with skin irritation in the ear canal. Im leaning toward Frontline Plus based on what you wrote. The amped-up version, Interceptor Plus, also contains praziquantel, which is used to treat tapeworms. WSU is the leader in identifying drugs that may be dangerous for dogs with the MDR1 mutation and can identify alternative medications and doses. Though all of these medicines had previously been approved by FDA scientists, now data received by the agency indicates that some animals receiving Bravecto, Nexgard, or Simparica have experienced adverse events such as muscle tremors, ataxia, and seizures.. Dinotefuran in particular is a strong pesticide, and all 3 of those ingredients combined are harsh on sensitive skin. I actually ended up choosing Interceptor Plus along with Credelio after looking at your research and getting some advice from fellow Aussie owners. He had been taking the it for about 2-3 months. 1x 20mg tablet for 11.1 to 22 pounds. It was very frightening. Thank you for this thorough and thoughtful work, Emily! Doses used for heartworm prevention are safe to use in these breeds of dogs. So heres the culmination of my research: information gathered from laboratory case studies, veterinarians, and Collie owners, breeders, and exhibitors. Its a nice alternative to Vectra 3D since its not as potent (so less chance for irritation), yet it also has some repellent properties. As the agency explained: Although FDA scientists carefully evaluate an animal drug prior to approval, there is the potential for new information to emerge after marketing, when the product is used in a much larger population. (New drugs continue to be highly monitored for the first three years following their release.). Simparica Trio can be used from 8 weeks of age in animals over 1.25kg. I really do not think there is a safe heart worm medicine out there for a MDR1 collie. Kudos to you for going out of your way to manage your Collies health, and good luck as you continue to search for what will work best for her!
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