Talk to your doctor for help in deciding if one is right for you. The Guardian covered the new figures, which found that around 6,000 non-smokers in the UK die of lung cancer each year. Apocrine tumors / extramammary Paget’s disease (closed to accrual) 40. Trophoblastic tumor: A) Choriocarcinoma (closed to accrual) 15. Drugs used in chemotherapy, such as pemetrexed and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. The ANZCTR is an online registry of clinical trials being undertaken in Australia, New Zealand and elsewhere. These targeted therapies inevitably stop working due to resistance, however I’m hoping that won’t happen for a while, and then there may be a new treatment available.”. It has been designed to provide Australians with consumer-friendly information about current cancer clinical trials. All trials on the list are supported by NCI.. NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. This study is being done to see if adding durvalumab to standard chemoradiation followed by additional durvalumab can extend patients life and / or prevent the tumor from coming back compared to the usual approach of chemoradiation alone followed by durvalumab. Osimertinib may stop the growth of tumor cells by blocking EGFR that is needed for cell growth in this type of cancer. The clinical trials on this list are for non-small cell lung cancer treatment. I started a clinical trial two and a half years ago and I responded very well with quick improvement. About 235,760 new cases of lung cancer (119,100 in men and 116,660 in women) About 131,880 deaths from lung cancer (69,410 in men and 62,470 in women) Lung cancer mainly occurs in older people. Neuroendocrine carcinoma including carcinoid of the lung (closed to accrual 12 / 19 / 2017) 24. Selpercatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. If … In fact, the spread (metastasis) is often discovered when a test, such as a CT scan or PET scanis done to determine the stage of your cancer. Results from POSEIDON, a phase 3 clinical trial in previously-untreated patients with stage 4 non-small cell lung cancer, showed that the triple combination of two immunotherapies—durvalumab and tremelimumab—given with standard chemotherapy improved progression-free survival vs. … This condition is now also referred to as adenocarcinoma in situ, minimally invasive adenocarcinoma, lepidic predominant adenocarcinoma, or invasive mucinous adenocarcinoma 13. Location: 16 locations, Treatment Clinical Trials for Non-Small Cell Lung Cancer, Complementary & Alternative Medicine (CAM), Coping with Your Feelings During Advanced Cancer, Late Effects of Childhood Cancer Treatment, Frederick National Laboratory for Cancer Research, Milestones in Cancer Research and Discovery, Tech Transfer & Small Business Partnerships, Step 1: Application Development & Submission, How to Work With Your Health Insurance Plan, Questions to Ask about Treatment Clinical Trials, Drugs Approved for Different Types of Cancer, Drugs Approved for Conditions Related to Cancer, Crizotinib in Treating Patients with Stage IB-IIIA Non-small Cell Lung Cancer That Has Been Removed by Surgery and ALK Fusion Mutations (An ALCHEMIST Treatment Trial), Testing the Timing of Pembrolizumab Alone or With Chemotherapy as First Line Treatment and Maintenance in Non-small Cell Lung Cancer, Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, ALCHEMIST Chemo-IO Study, Nivolumab and Ipilimumab in Treating Patients with Rare Tumors, Testing the Addition of an Antibody to Standard Chemoradiation followed by the Antibody for One Year to Standard Chemoradiation followed by One Year of the Antibody in Patients with Unresectable Stage III Non-Small Cell Lung Cancer, Targeted Treatment for ALK Positive Patients Who Have Previously Been Treated for Non-squamous Non-small Cell Lung Cancer, Testing the Addition of the Pill Chemotherapy, Cabozantinib, to the Standard Immune Therapy Nivolumab Compared to Standard Chemotherapy for Non-small Cell Lung Cancer, Targeted Treatment for RET Fusion-Positive Advanced Non-Small Cell Lung Cancer (A LUNG-MAP Treatment Trial), AZD9291 (Osimertinib) with or without Bevacizumab as Initial Treatment for Patients with EGFR-Mutant Lung Cancer, Comparing Standard Treatment Alone to Radiation Therapy with or without Surgery with Standard Treatment for Patients with Limited Metastatic Non-Small Cell Lung Cancer, Testing the Addition of the Drug Atezolizumab to the Usual Radiation Treatment for Patients with Early Non-small Cell Lung Cancer, Testing the Effects of MK-3475 (Pembrolizumab) with or without the Usual Chemotherapy Treatment for Patients 70 Years of Age and Older with Advanced Non-small Cell Lung Cancer, Accelerated Hypofractionated or Conventionally Fractionated Radiotherapy and Durvalumab in Treating Patients with Stage II-III Non-small Cell Lung Cancer, Study of Radiation Therapy Followed by Atezolizumab in Stage II or III Non-small Cell Lung Cancer Patients, Comparing Photon Therapy to Proton Therapy to Treat Patients with Lung Cancer, Sublobar Resection or Stereotactic Ablative Radiotherapy in Treating Patients with Stage I Non-small Cell Lung Cancer, Phase 2 Study of Poziotinib in Patients With NSCLC Having EGFR or HER2 Exon 20 Insertion Mutation, A Phase 1 / 2, Study Evaluating the Safety, Tolerability, PK, and Efficacy of AMG 510 in Subjects With Solid Tumors With a Specific KRAS Mutation (CodeBreak 100), Study of Cabozantinib in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid Tumors, Durvalumab vs Placebo With Stereotactic Body Radiation Therapy in Early Stage Unresected Non-small Cell Lung Cancer Patients, Study of TSR-042, an Anti-programmed Cell Death-1 Receptor (PD-1) Monoclonal Antibody, in Participants With Advanced Solid Tumors, Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1 / 2 / 3 (Trk A / B / C), ROS1, or ALK Gene Rearrangements (Fusions), Dose-Escalation / Expansion of RMC-4630 and Cobimetinib in Relapsed / Refractory Solid Tumors and RMC-4630 and Osimertinib in EGFR Positive Locally Advanced / Metastatic NSCLC, Pilot Immunotherapy Study With Autologous T-cells Specific for NY-ESO-1 / LAGE-1a-positive Advanced NSCLC Either Alone or in Combination With Pembrolizumab, A Study of a Personalized Cancer Vaccine Targeting Shared Neoantigens, U.S. Department of Health and Human Services. Squamous cell carcinoma variants of the genitourinary (GU) system 19. Non-epithelial tumors of the ovary: A) Germ cell tumor of ovary B) Mullerian mixed tumor and adenosarcoma (closed to accrual 03 / 30 / 2018) 14. These drugs target specific genetic mutations that can underlie a particular cancer. We pay our respects to their cultures, and to elders both past present and emerging. Transitional cell carcinoma other than that of the renal, pelvis, ureter, or bladder (closed to accrual) 16. Location: 23 locations, This is an open-label, multicenter, global Phase 2 basket study of entrectinib (RXDX-101) for the treatment of patients with solid tumors that harbor an NTRK1 / 2 / 3, ROS1, or ALK gene fusion. Crizotinib may stop the growth of tumor cells by blocking the ALK protein from working. Europeans face significant challenges to participate in lung cancer clinical trials Sep 10, 2019 Study quantifies impact of NCI-sponsored trials on clinical cancer care Information and help. Pheochromocytoma, malignant (closed to accrual) 25. Here’s the latest news in lung cancer research that the Lung Cancer Foundation of America staff has curated for our community. Location: 31 locations, This is a Phase 2, open-label, multi-center study to evaluate the efficacy and the safety / tolerability of poziotinib in seven patient cohorts for up to 603 previously treated and treatment-naïve NSCLC patients. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. This causes cancer cells to divide more rapidly. Location: 17 locations, The purpose of this study is to evaluate the dose, safety, immunogenicity and early clinical activity of GRT-C903 and GRT-R904, a neoantigen-based therapeutic cancer vaccine, in combination with immune checkpoint blockade, in patients with advanced or metastatic non-small cell lung cancer, microsatellite stable colorectal cancer, pancreatic cancer, and shared neoantigen-positive tumors. Location: 472 locations, This phase II trial compares cabozantinib alone and the combination of cabozantinib and nivolumab to standard chemotherapy in the treatment of patients with non-squamous non-small cell lung cancer (NSCLC). 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